Despite significant resources that have been targeted at eradicating cancer, it remains the second leading cause of death in the United States today. However, there have been significant strides forward in its treatment, including an increase in the understanding of the molecular etiology of certain cancers. These accomplishments will allow therapeutic approaches to be developed that will be more selective and specific for the cancer cell. There has been "explosive" growth of the basic understanding of the molecular etiology of certain cancers. This text provides state-of-the-art information on new approaches in cancer prevention, detection, diagnosis, and treatment that may have signigicant therapeutic implications.